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Bioperine: What is it and Why is it in Fat Burners?

Bioperine: What is it and Why is it in Fat Burners?

By: Robbie Durand

Bioperine is a plant extract derived from two types of pepper plants, namely, long pepper (Piper longum) and black pepper (Piper negrum). The natural chemical compound is a patented product made from the standardized piperine extract from the above mentioned pepper species. BioPerine® from Sabinsa (East Windsor, NJ) is a patented standardized extract from black pepper, containing not less than 95 percent piperine.

Pharmacological studies have shown that piperine reduces inflammation and pain, possesses anticonvulsant and antiulcer activity, protects the liver, has deleterious and antioxidant activity. Results from previous studies demonstrated that piperine showed anxiolytic and antidepressant like activity. Piperine also inhibited monoamine oxidase (MAO) activity, and increased the levels of noradrenaline and serotonin in some regions of the mouse brain.

All of these characteristics make it perfect for the dieting male or female, but more importantly, it is a clinically proven bio availability enhancer for nutrients. It shows increased blood supply to the GI tract, increased emulsifying content of the gut and increased active nutrient transport.

According to the Merck Manuals, bioavailability is the extent and rate within which an active drug enters systemic circulation after passing through the first-pass metabolism sites, namely, the intestinal wall and liver. Bioperine has been shown to boost the bioavailability of nutrients, namely beta-carotene, vitamin B, B6, vitamin C, selenium, and co-enzyme Q10, and other ingredients found in various supplements — including male enhancement supplements.

According to research conducted by the manufacturer, bioperine substantially increases the absorption of selenium (30%), beta carotene (60%), vitamin B6 (140-250%) as well as coenzyme Q10. So if your fat burner does not contain bioperine, it should as its clinically been found to enhance the active transport of nutrients and based on a study, it enhances the effect of caffeine.

Vijayakumar RS, Surya D, Nalini N. Antioxidant efficacy of black pepper (Pipernigrum L.) and piperine in rats with high fat diet induced oxidative stress. Redox Rep. 2004;9(2):105-10.

Selvendiran K, Thirunavukkarasu C, Singh JP, Padmavathi R, Sakthisekaran D. Chemopreventive effect of piperine on mitochondrial TCA cycle and phase-I and glutathione-metabolizing enzymes in benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. Mol Cell Biochem. 2005 Mar;271(1-2):101-6.

Myhrer T. Neurotransmitter systems involved in learning and memory in the rat: a meta-analysis based on studies of four behavioral tasks. Brain Res Brain Res Rev. 2003;41(2–3):268–287.

Jin UH, Kim JH, Chang GT, Kim JK, Chung KH, Kim CH. Enhancement of learning and memory by a medicinal formulation, Saenhyetang, in mice. J Ethnopharmacol. 2007;109(2):271–280.

Gupta SK, Bansal P, Bhardwaj RK, Velpandian T. Comparative anti-nociceptive, anti-inflammatory and toxicity profile of nimesulide vs nimesulide and piperine combination. Pharmacol Res. 2000;41(6):657–662.

Bai YF, Xu H. Protective action of piperine against experimental gastric ulcer. Acta Pharmacol Sin. 2000;21(4):357–359.

D’Hooge R, Pei YQ, Raes A, Lebrun P, van Bogaert PP, de Deyn PP. Anticonvulsant activity of piperine on seizures induced by excitatory amino acid receptor agonists. Arzneimittelforschung. 1996; 46(6):557–560.

Koul IB, Kapil A. Evaluation of the liver protective potential of piperine, an active principle of black and long peppers. Planta Med. 1993;59(5):413–417.

Malini T, Manimaran RR, Arunakaran J, Aruldhas MM, Govindarajulu P. Effects of piperine on testis of albino rats. J Ethnopharmacol. 1999; 64(3):219–225.

Selvendiran K, Singh JP, Krishnan KB, Sakthisekaran D. Cytoprotective effect of piperine against benzopyrene induced lung cancer with reference to lipid peroxidation and antioxidant system in Swiss albino mice. Fitoterapia. 2003;74(1–2):109–115.

Lee SA, Hong SS, Han XH, et al. Piperine from the fruits of Piper longum with inhibitory effect on monoamine oxidase and antidepressant- like activity. Chem Pharm Bull (Tokyo). 2005;53(7):832–835.

Li S, Wang C, Li W, Koike K, Nikaido T, Wang MW. Antidepressant- like effects of piperine and its derivative, antiepilepsirine. J Asian Nat Prod Res. 2007;9(3–5):421–430.

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