L-ISOLEUCINE MAY HELP TO:
- SUPPORT BLOOD FLOW *
- ASSIST NITRIC OXIDE PRODUCTION*
L-Norvaline is an analog of the branched chain amino acid Valine. It has been proposed that L-Norvaline inhibits the arginase enzyme thus increasing arginine concentrations. L-norvaline also exhibits anti-inflammatory properties independently of its effect on inhibition of arginase activity and increased NO production.
Chang CI, Liao JC, Kuo L. Arginase modulates nitric oxide production in activated macrophages. Am J Physiol. 1998 Jan;274(1 Pt 2):H342-8
F. Ming, A. G. Rajapakse, J. M. Carvas, J. Ruffieux, and Z. Yang, “Inhibition of S6K1 accounts partially for the anti inflammatory effects of the arginase inhibitor L-norvaline,” BMC Cardiovascular Disorders, vol. 9, article 12, 2009.
Mihail V. Pokrovskiy, Mihail V. Korokin, Svetlana A. Tsepeleva, et al., “Arginase Inhibitor in the Pharmacological Correction of Endothelial Dysfunction,” International Journal of Hypertension, vol. 2011, Article ID 515047, 4 pages, 2011.
El-Bassossy HM, El-Fawal R, Fahmy A, Watson ML. Arginase inhibition alleviates hypertension in the metabolic syndrome. Br J Pharmacol. 2013 Jun;169(3):693-703. Ming XF, Rajapakse AG, Carvas JM, Ruffieux J, Yang Z. Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline. BMC Cardiovasc Disord. 2009 Mar 13;9:12.