Super Pumped!! Citrulline and Glutathione Increases Nitric Oxide

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Super Pumped!! Citrulline and Glutathione Increases Blood Flow

L-citrulline supplementation has been shown to exhibit several beneficial effects on the cardiovascular system.  Citrulline works in conjunction with L-arginine to enhance muscle blood flow.  In a recent clinical study, l-citrulline supplementation dose-dependently increased plasma l-arginine levels in healthy human volunteers more effectively than equivalent doses of l-arginine itself. Furthermore, other researchers have demonstrated in clinical trials that l-citrulline supplementation functionally improves arterial stiffness, meaning it improved blood vessel dilation.  So both work synergistically together but what according to research, combining the two work better than each one separately.   In seems that a combining the amino acid L-citrulline and glutathione may boost nitrite and NO levels more than L-citrulline by itself. 

Glutathione is an important antioxidant and plays a major role in the detoxification of endogenous metabolic products.  Glutathione acts as a powerful antioxidant to preserve and protect the brain and other body tissues by protecting them from the damage of free radicals.  It has been shown is some mammalian cell types, that glutathione and nitric oxide activity are linked. This suggests that glutathione may play an important role in protection against oxidative reaction of nitric oxide, thus contributing to the sustained release of nitric oxide. Therefore, combining L-citrulline with glutathione may augment the production of NO.

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“Rise above the rest with Juggernaut X. With eight grams of Citrulline per serving, our newest pre-workout includes all of the necessary ingredients to help you reach new heights and achieve your fitness goals.”

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The present study suggests that the oral supplementation of L-citrulline combined with glutathione increases nitric oxide. Therefore, glutathione may play an important role in protection against oxidative reaction of nitric oxide, thus contributing to the sustained release of nitric oxide.

Researchers had 60-resistance-trained males randomly assigned to receive supplements containing L-citrulline only (2 g/day), glutathione only (1 g/day), a combination of the two (L-citrulline at 2 g/day and glutathione at 200 mg/day), or a placebo for seven days. After the week of supplementation the men then underwent a resistance exercise session. At the end of the study,men in the combination group had significantly higher nitrite and nitric oxide at 30 min post-exercise, compared with the placebo group. In addition, a there were small increases in cyclic guanosine monophosphate (cGMP) after citrulline and glutathione supplementation. Intracellular cGMP serves as a cellular messenger and plays a role in a variety of biological processes, and in human blood vessels, results in vasodilation. The data suggest that oral supplementation of L-citrulline combined with glutathione provides an augmenting effect on plasma nitric oxide. The present study suggests that the oral supplementation of L-citrulline combined with glutathione increases nitric oxide. Therefore, glutathione may play an important role in protection against oxidative reaction of nitric oxide, thus contributing to the sustained release of nitric oxide.

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Glutathione has the unique ability of maximizing the activity of all other antioxidants, including vitamins C and E, CoQ10, alpha lipoic acid, and the fresh veggies and fruits you eat. It also removes toxins from your cells and protects you from the damaging effects of radiation, chemicals, and environmental pollutants.  Interestingly, a study published in the International Dairy Journal suggests whey protein beverages are effective at reducing blood pressure in people at risk for hypertension. The beneficial effects of whey protein may be related to its influence on nitric oxide production, which plays a role in blood pressure regulation.  Be on the lookout for the new wave of nitric oxide boosters to contain glutathione.

S. McKinley-Barnard, T. Andre, M. Morita, D.S. Willoughby. Combined L-citrulline and glutathione supplementation increases the concentration of markers indicative of nitric oxide synthesis. Journal of the International Society of Sports Nutrition  2015, 12:27  doi:10.1186/s12970-015-0086-7

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