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Agmatine

22.5 grams
$25.29
$31.65


Serving Size 1 Scoop (750mg)
Servings Per Container 30
 
Amount Per Serving   % DV*
 
Agmatine Sulfate 750mg **
 
* (%) Percent Daily Values (DV) are based on a 2,000 calorie diet.
** Daily Value (DV) not established
Directions:

As a dietary supplement for adults, mix one serving (1 Scoop) into 8 ounces of cold water or beverage of choice 30 minutes prior to training. Optimal intake may be one serving (1 Scoop) twice a day.

Warnings:

Seek advice from a physician before consuming this product. Do not use if you are contemplating pregnancy, pregnant, nursing, prone to dehydration, or exposed to excessive heat. Reduce or discontinue use of this product if sleeplessness, tremors, dizziness, nervousness, headaches, or heart palpitations occur. This product is only intended for use by healthy adults 18 years of age or older. Discontinue use two weeks prior to surgery. Keep out of reach of children and pets. Store in a cool dry place away from direct sunlight. Consumer is responsible and assumes all risks, liabilities, and consequences related to the use of this product, including compliance with the rules and regulations of all governing bodies or other entities having jurisdiction over any sport or athletic activity in which he/she participates, as well as any career regulations.

References:
1. Gao, Y., et al. Agmatine: a novel vasodilator substance. Life Sciences. 57(8):PL83-86, 1995.
2. Halaris A, Piletz JE. Imidazoline receptors: possible involvement in the pathophysiology and treatment of depression. Hum Psychopharmacol. 16(1):65-69, 2001.
3. Kalra, S.P., et al. Agmatine, a novel hypothalamic amine, stimulates pituitary luteinizing hormone release in vivo and hypothalamic luteinizing hormone-releasing in vivo. Neuroscience Letters. 194 (3): July 21, 1995; 165-168.
4. Morgan, N.G., et al. Characterization of the imidazoline binding site in regulation of insulin secretion. Annals of the New York Academy of Sciences. 763:361-373, 1995.
5. Nishimura K, Shiina R, Kashiwagi K, and Igarashi K. Decrease in Polyamines with Aging and Their Ingestion from Food and Drink. J of Biochem. 139(1):81-90, 2006.
6. Raasch, W. et al. Agmatine, the bacterial amine is widely distributed in mammalian tissues. Life Sciences. 56(26):2319-2330, 1995.
7. Raghavan SA, Dikshit M. Vascular regulation by the L-arginine metabolites, nitric oxide and agmatine. Pharmacol Res. 49(5):397-414. Review, 2004.
8. Yananli H, Goren MZ, Berkman K, Aricioglu F. Effect of agmatine on brain l-citrulline production during morphine withdrawal in rats: A microdialysis study in nucleus accumbens. Brain Res. 2007 Feb 9;1132(1):51-58, 2006.
9. Zarandi M, Serfozo P, Zsigo J, Deutch AH, Janaky T, Olsen DB, Bajusz S, Schally AV. Potent agonists of growth hormone-releasing hormone. II. Pept Res. 5(4):190-3, 1992.
10. Zhu MY, Wang WP, Cai ZW, Regunathan S, & Ordway G. (2008). Exogenous agmatine has neuroprotective effects against restraint-induced structural changes in the rat brain. The European Journal of Neuroscience. 27(6), 1320-32.



Agmatine may support muscle pumps, nutrient transport, nutrient partitioning (greater number of calories shunted towards muscle tissue and less stored in fat cells) and blood flow. Agmatine appears to support muscle pumps in various ways:

Agmatine may support nutrient partitioning, which leads to more muscle glycogen (carbohydrates stored in muscle tissues) stored, thus more water retained in the muscle. This can lead to a “fuller” look to the muscle and muscle pumps.*

Agmatine appears to assist NO production by playing a competitive inhibitor role of the enzyme nitric oxide synthase. The nutrient partitioning effects of Agmatine may be due to its potential ability to support the insulin response to carbohydrates, as well as the blood flow to the muscle seen with nitric oxide production.*



Defining Agmatine: Arginine vs. Agmatine

Arginine is well renowned for its capacity to support protein synthesis, sustain the endogenous production of creatine, support insulin sensitivity via attenuation of blood glucose, as well as its assistance during the removal of nitrogenous waste in the urea cycle.*

Until recently, Arginine has been labeled as a go to supplement in many athletic and bodybuilding regimens. However, with the growing literature and knowledge on the potential ergogenic value of Agmatine, athletes are beginning to gear their supplementation needs in a new direction. Agmatine is likely the one molecule to take part in more metabolic processes than Arginine. There exists nineteen well-documented mechanisms of action suggested in the research and a minimum of thirteen elicit direct benefits to the athlete or bodybuilder with even more effects emerging as the research continues.*

 

 



Agmatine as an Ergogenic Aid



Agmatine supports insulin production which elicits better insulin responses. Increased insulin response has been shown to have positive effects on body composition and musculature.*


Agmatine offers potential assistance in kidney function via stimulation of the glomerular filtration rate (GFR). This can prep the bodybuilder as various nitrogenous waste products are eliminated through this system.*


Agmatine serves as a potential aid in the recovery process of the athlete. It can also support the effects of analgesics required during recuperation from injury.*


Agmatine modulates NO through a variety of mechanisms. It stimulates some types of nitric oxide synthase (NOS) while restraining others. This is crucial to the proper functioning of the polyamine biosynthetic pathways. Specific to body composition, Agmatine has an independent role of testosterone and insulin management on lipid (fat) metabolism.*


Agmatine offers antioxidant properties. This is of particular interest to the committed athlete. The load an athlete endures throughout a strict training regimen directly affects the free-radical buildup in the human body and can have damaging effects if the buildup continues. Agmatine can serve as a protection from these unwanted effects that free radicals impose on the body.*


Agmatine acts as a novel neurotransmitter and can support a healthy mood. It can be beneficial to those looking to achieve a mental edge, whether it be in the gym or in everyday life.*



As a result of these effects, supplementing any athletic and/or bodybuilding regimen with Agmatine may support athletic performance, fat loss, and muscle size, vascularity, and fullness. Additional benefits including protection against free radical damage and recovery support also add to the quality of everyday life. Arginine was the miracle worker of its time, but Agmatine may appear to be an even better supplemental option in regards to body physique advancements and performance.*




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